Biosisto offers reference materials that match the strains mentioned in these ISO standards for cosmetics. These reference materials are essential for quality control to ensure that microbiological testing methods function correctly and provide accurate results.

ISO 21149 Cosmetics — Microbiology — Enumeration and detection of aerobic mesophilic bacteria
This standard specifies a method for detecting and enumerating aerobic mesophilic bacteria in cosmetics, ensuring the bacterial load is within acceptable limits.

ISO 16212 Cosmetics — Microbiology — Enumeration of yeast and mould
This standard provides a method for enumerating yeasts and molds in cosmetic products, which is important for preventing spoilage and ensuring product stability.

ISO 18415 Cosmetics — Microbiology — Detection fo specified and non-specified miroorganisms
This standard outlines the procedures for detecting specific pathogenic microorganisms, including Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans, potential contaminants in cosmetics.

ISO 22717 Cosmetics — Microbiology — Detection of Pseudomonas aeruginosa
This standard focuses on detecting Pseudomonas aeruginosa, a bacterium that can cause infections, particularly in immunocompromised individuals.

ISO 22718 Cosmetics — Microbiology — Detection of Staphylococcus aureus
This standard specifies a method for detecting Staphylococcus aureus, a common skin pathogen that can cause various skin infections.

ISO 18416 Cosmetics — Microbiology — Detection of Candida albicans
This standard provides a method for detecting Candida albicans, a yeast that can cause infections, especially in individuals with compromised immune systems.

ISO 11930 Cosmetics Microbiology – Evaluation of the antimicrobial protection of a cosmetic product
This standard is for evaluating the antimicrobial protection of a cosmetic product.
This standard is crucial for ensuring the safety and stability of cosmetic products by determining their ability to resist microbial contamination.

The purpose of this standard is:
– To assess the effectiveness of preservatives in cosmetic products.
– To ensure the microbial stability of products during their shelf life and usage.

This involves intentionally contaminating the cosmetic product with a known quantity of specific microorganisms and monitoring the product over time to see if the microbial population decreases to acceptable levels. Typically, bacteria and fungi, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus brasiliensis, are used. The product must show a significant reduction in microbial count within a specified timeframe, indicating effective preservation.


Below is a list of suitable CRMs for cosmetic analysis.
We can produce it custom if the strain you require is not listed. If you would like to explore this option, please feel free to email


Aspergillus brasiliensisCRM-ABR.00053BH00034ATCC 16404, CBS 733.88ISO 11930
Burkholderica cepaciaCRM-BCEPA.BHATCC 25416, CCUG 13226ISO 11930
Candida albicansCRM-CAL.00054BH00054ATCC 10231, CBS 6431ISO 11930
ISO 16212
ISO 18415
ISO 18416
Escherichia coli CRM-ECO.00012BH00012ATCC 8739, NCCB 72002ISO 11930
ISO 18415
ISO 21149
ISO 21150
Pseudomonas aeruginosaCRM-PAE.00026BH00026ATCC 9027, NCCB 100424ISO 11930
ISO 18415
ISO 21149
ISO 22717
Penicillium expansumCRM-PEX.BHATCC 36200, CBS 230.38ISO 11930
Proteus mirabilisCRM-PMI.BHATCC 14153, CCUG 32232ISO 11930
Staphylococcus aureusCRM-SAU.00032BH00032ATCC 6538, NCCB 46064ISO 11930
ISO 18415
ISO 21149
ISO 22718
Trichoderma virideCRM-TVI.BHATCC 28020, CBS 394.92ISO 11930



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Biosisto - Quality in Control

Microbiological laboratories should be able to receive reliable analysis without much overhead. A microbiological analyst must be able to focus on the primary activities, for example analysis of the sample material. Quality control should support the analyst in a logical and simple manner. By using modern information technology, process control and quality assurance are designed smarter and more effective.

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